ARFIP2

ARFIP2
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1I49, 1I4D, 1I4L, 1I4T, 4DCN
Tanımlayıcılar
Başka adlar	ARFIP2, POR1, ADP ribozillenme faktörü etkileşimli protein 2, ADP ribozilasyon faktörü etkileşimli protein 2
Dış kimlikler	OMIM: 601638 MGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	6,481,479 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• phosphatidylinositol-4-phosphate binding; • protein domain specific binding; • GO:0001948, GO:0016582 protein bağlanması; • GTP binding; • identical protein binding; • cadherin binding; • GTP-dependent protein binding; • phospholipid binding;
Hücresel bileşeni	• cell cortex; • trans-Golgi network membrane; • Hücre zarı; • ruffle; • Sitozol; • sitoplazma;
Biyolojik süreci	• ruffle organization; • small GTPase mediated signal transduction; • actin cytoskeleton organization; • regulation of Arp2/3 complex-mediated actin nucleation; • lamellipodium assembly; • intracellular protein transport;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	23647
	76932
	ENSG00000132254
	ENSMUSG00000030881
	P53365
	Q8K221
	NM_001242854; NM_001242855; NM_001242856; NM_012402
	NM_029802
NP_001229783; NP_001229784; NP_001229785; NP_036534; NP_001357335;
	NP_001357337; NP_001357338; NP_001357340; NP_001357341; NP_001357342; NP_001363487; NP_001363488; NP_001363489; NP_001363490; NP_001363491; NP_001363492; NP_001363493
	NP_084078
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Arfaptin 2, insanlarda ARFIP2 geni tarafından kodlanan bir proteindir.^[4]^[5]^[6]

Etkileşimler[değiştir | kaynağı değiştir]

ARFIP2'nin Arf6,^[7]^[8] ARF3,^[5] ARF5 ve RAC1 ile etkileşime girdiği gösterilmiştir.^[4]^[9]

Konuyla ilgili yayınlar[değiştir | kaynağı değiştir]

D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (Eylül 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). ss. 5445-54. doi:10.1093/emboj/16.17.5445. PMC 1170175 $2. PMID 9312003.
Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (Mayıs 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). ss. 215-9. doi:10.1038/35075620. PMID 11346801.
Shin OH, Exton JH (Ağustos 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). ss. 1267-73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C (Mart 2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3). ss. 240-5. doi:10.1038/ncb761. PMID 11854752.
Lu L, Hong W (Eylül 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9). ss. 3767-81. doi:10.1091/mbc.E03-01-0864. PMC 196566 $2. PMID 12972563.
Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S (Haziran 2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23). ss. 22021-8. doi:10.1074/jbc.M407528200. PMID 15809304.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Ekim 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). ss. 1173-8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

Dış bağlantılar[değiştir | kaynağı değiştir]

Human ARFIP230 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genome location and ARFIP2^{[ölü/kırık bağlantı]} gene details page in the UCSC Genome Browser.

Kaynakça[değiştir | kaynağı değiştir]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15). Ağustos 1996. ss. 3778-86.
^ ^a ^b "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9). Şubat 1997. ss. 5421-9.
^ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.
^ "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). Eylül 1997. ss. 5445-54.
^ "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). Ağustos 2001. ss. 1267-73.
^ "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). Mayıs 2001. ss. 215-9.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8670882-4] "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15). Ağustos 1996. ss. 3778-86.

[pmid9038142-5] "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9). Şubat 1997. ss. 5421-9.

[entrez-6] "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

[pmid9312003-7] "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). Eylül 1997. ss. 5445-54.

[pmid11478794-8] "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). Ağustos 2001. ss. 1267-73.

[pmid11346801-9] "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). Mayıs 2001. ss. 215-9.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]