ARL2

ARL2
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	3DOE, 3DOF
Tanımlayıcılar
Başka adlar	ARL2
Dış kimlikler	OMIM: 601175 MGI: 1928393 HomoloGene: 1260 GeneCards: ARL2
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	65,022,184 bç
Gen ontolojisi
Moleküler işlevi	• nucleotide binding; • GTP binding; • GTPase inhibitor activity; • GO:0001948, GO:0016582 protein bağlanması; • GO:0006184 GTPase activity; • GDP binding;
Hücresel bileşeni	• sitoplazma; • sentrozom; • lateral plasma membrane; • mitochondrial intermembrane space; • intracellular anatomical structure; • microtubule organizing center; • mitochondrial matrix; • mitokondri; • Hücre iskeleti; • hücre çekirdeği; • Çekirdekçik; • Golgi aygıtı; • Sitozol; • focal adhesion; • Sil; • microtubule cytoskeleton;
Biyolojik süreci	• tubulin complex assembly; • regulation of insulin secretion; • GO:0034259 negative regulation of GTPase activity; • regulation of microtubule polymerization; • bicellular tight junction assembly; • positive regulation of microtubule polymerization; • Hücre döngüsü; • maintenance of protein location in nucleus; • positive regulation of cell-substrate adhesion; • centrosome cycle;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	402
	56327
	ENSG00000213465
	ENSMUSG00000024944
	P36404
	Q9D0J4
	NM_001667; NM_001199745
	NM_019722
	NP_001186674; NP_001658
	NP_062696
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

ADP-ribozillenme faktörü benzeri protein 2, insanlarda ARL2 geni tarafından kodlanan bir proteindir.^[4]^[5]^[6]

İşlev[değiştir | kaynağı değiştir]

ADP-ribozillenme faktörü (ARF) genleri, RAS süper ailesinin küçük GTP bağlayıcı proteinleridir. ARL2, ARF benzeri genlerin işlevsel olarak farklı bir grubunun bir üyesidir.^[6]

Etkileşimler[değiştir | kaynağı değiştir]

ARL2'nin Unc-119,^[7] TBCD^[8]^[9] ve PDE6D ile etkileşime girdiği gösterilmiştir.^[10]^[11]

Kaynakça[değiştir | kaynağı değiştir]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213465 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes". Proc. Natl. Acad. Sci. U.S.A. 90 (19). Kasım 1993. ss. 8952-6.
^ "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7). Eylül 1997. ss. 725-35.
^ ^a ^b "Entrez Gene: ARL2 ADP-ribosylation factor-like 2". 5 Aralık 2010 tarihinde kaynağından arşivlendi.
^ "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1-3). Ocak 2003. ss. 26-32.
^ "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42). Ekim 2003. ss. 40829-36.
^ "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5). Mayıs 2000. ss. 1087-96.
^ "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). Ekim 2005. ss. 1173-8.
^ "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9). Mayıs 2002. ss. 2095-106.

Dış bağlantılar[değiştir | kaynağı değiştir]

Human ARL2 30 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genome location and ARL2^{[ölü/kırık bağlantı]} gene details page in the UCSC Genome Browser.

Konuyla ilgili yayınlar[değiştir | kaynağı değiştir]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2). ss. 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2). ss. 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bhamidipati A, Lewis SA, Cowan NJ (2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5). ss. 1087-96. doi:10.1083/jcb.149.5.1087. PMC 2174823 $2. PMID 10831612.
Sharer JD, Shern JF, Van Valkenburgh H, Wallace DC, Kahn RA (2002). "ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter". Mol. Biol. Cell. 13 (1). ss. 71-83. doi:10.1091/mbc.01-05-0245. PMC 65073 $2. PMID 11809823.
Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9). ss. 2095-106. doi:10.1093/emboj/21.9.2095. PMC 125981 $2. PMID 11980706.
Antoshechkin I, Han M (2002). "The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis". Dev. Cell. 2 (5). ss. 579-91. doi:10.1016/S1534-5807(02)00146-6. PMID 12015966.
Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G (2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1-3). ss. 26-32. doi:10.1016/S0014-5793(02)03766-3. PMID 12527357.
Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42). ss. 40829-36. doi:10.1074/jbc.M308678200. PMID 12912990.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). ss. 1173-8. doi:10.1038/nature04209. PMID 16189514.
Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA (2006). "Arl2 and Arl3 regulate different microtubule-dependent processes". Mol. Biol. Cell. 17 (5). ss. 2476-87. doi:10.1091/mbc.E05-10-0929. PMC 1446103 $2. PMID 16525022.
Beghin A, Honore S, Messana C, Matera EL, Aim J, Burlinchon S, Braguer D, Dumontet C (2007). "ADP ribosylation factor like 2 (Arl2) protein influences microtubule dynamics in breast cancer cells". Exp. Cell Res. 313 (3). ss. 473-85. doi:10.1016/j.yexcr.2006.10.024. PMID 17188265.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213465 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8415637-4] "Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes". Proc. Natl. Acad. Sci. U.S.A. 90 (19). Kasım 1993. ss. 8952-6.

[pmid9253601-5] "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7). Eylül 1997. ss. 725-35.

[entrez-6] "Entrez Gene: ARL2 ADP-ribosylation factor-like 2". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

[pmid12527357-7] "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1-3). Ocak 2003. ss. 26-32.

[pmid12912990-8] "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42). Ekim 2003. ss. 40829-36.

[pmid10831612-9] "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5). Mayıs 2000. ss. 1087-96.

[pmid16189514-10] "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). Ekim 2005. ss. 1173-8.

[pmid11980706-11] "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9). Mayıs 2002. ss. 2095-106.

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