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Sayfanın 06.48, 25 Şubat 2022 tarihindeki hâli

Justus von Liebig's synthesis of oxamide from dicyan and water represents the first organocatalytic reaction, with acetaldehyde further identified as the first discovered pure "organocatalyst", which act similarly to the then-named "ferments", now known as enzymes.[1][2]

Organokataliz is a form of catalysis in which the rate of a chemical reaction is increased by an organic catalyst. This "organocatalyst" consists of carbon, hydrogen, sulfur and other nonmetal elements found in organic compounds.[3][4][5][6][7][8] Because of their similarity in composition and description, they are often mistaken as a misnomer for enzymes due to their comparable effects on reaction rates and forms of catalysis involved.

Kaynakça

  1. ^ Justus von Liebig, Justus (1860). "Ueber die Bildung des Oxamids aus Cyan". Annalen der Chemie und Pharmacie. 113 (2): 246–247. doi:10.1002/jlac.18601130213. 
  2. ^ W. Langenbeck (1929). "Über organische Katalysatoren. III. Die Bildung von Oxamid aus Dicyan bei Gegenwart von Aldehyden". Liebigs Ann. 469: 16–25. doi:10.1002/jlac.19294690103. 
  3. ^ Berkessel, A.; Groeger, H. (2005). Asymmetric Organocatalysis. Weinheim: Wiley-VCH. ISBN 978-3-527-30517-9. 
  4. ^ Special Issue: List, Benjamin (2007). "Organocatalysis". Chem. Rev. 107 (12): 5413–5883. doi:10.1021/cr078412e.  Geçersiz |doi-access=free (yardım)
  5. ^ Peter I. Dalko; Lionel Moisan (2004). "In the Golden Age of Organocatalysis". Angew. Chem. Int. Ed. 43 (39): 5138–5175. doi:10.1002/anie.200400650. PMID 15455437. 
  6. ^ Matthew J. Gaunt; Carin C.C. Johansson; Andy McNally; Ngoc T. Vo (2007). "Enantioselective organocatalysis". Drug Discovery Today. 12 (1/2): 8–27. doi:10.1016/j.drudis.2006.11.004. PMID 17198969. 
  7. ^ Dieter Enders; Christoph Grondal; Matthias R. M. Hüttl (2007). "Asymmetric Organocatalytic Domino Reactions". Angew. Chem. Int. Ed. 46 (10): 1570–1581. doi:10.1002/anie.200603129. PMID 17225236. 
  8. ^ Peter I. Dalko; Lionel Moisan (2001). "Enantioselective Organocatalysis". Angew. Chem. Int. Ed. 40 (20): 3726–3748. doi:10.1002/1521-3773(20011015)40:20<3726::AID-ANIE3726>3.0.CO;2-D.