CHKA: Revizyonlar arasındaki fark
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İçerik silindi İçerik eklendi
"CHKA" sayfasının çevrilmesiyle oluşturuldu. Etiketler: İçerik Çevirmeni İçerik Çevirmeni 2 |
Değişiklik özeti yok |
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| 13. satır: | 13. satır: | ||
== Ek okuma == |
== Ek okuma == |
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*{{cite journal | vauthors=Spanner S, Ansell GB |title=Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat forebrain |journal=Biochem. J. |volume=178 |issue= 3 |pages= 753–60 |year= 1979 |pmid= 36885 |doi= | pmc=1186576 }} |
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*{{cite journal | vauthors=Spanner S, Ansell GB |title=Choline and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain |journal=Adv. Exp. Med. Biol. |volume=101 |issue= |pages= 237–45 |year= 1978 |pmid= 208357 |doi= 10.1007/978-1-4615-9071-2_23}} |
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*{{cite journal | vauthors=Kaplan O, Cohen JS |title=Lymphocyte activation-31P magnetic resonance studies of energy metabolism and phospholipid pathways |journal=ImmunoMethods |volume=4 |issue= 2 |pages= 139–47 |year= 1994 |pmid= 8069533 |doi=10.1006/immu.1994.1015 }} |
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*{{cite journal | vauthors=Price DJ, Rivnay B, Fu Y |title=Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5915–20 |year= 1997 |pmid= 9038210 |doi=10.1074/jbc.272.9.5915 |display-authors=etal}} |
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*{{cite journal | vauthors=Ross BM, Moszczynska A, Blusztajn JK |title=Phospholipid biosynthetic enzymes in human brain |journal=Lipids |volume=32 |issue= 4 |pages= 351–8 |year= 1997 |pmid= 9113621 |doi=10.1007/s11745-997-0044-x |display-authors=etal}} |
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*{{cite journal | vauthors=Nakagami K, Uchida T, Ohwada S |title=Increased choline kinase activity and elevated phosphocholine levels in human colon cancer |journal=Jpn. J. Cancer Res. |volume=90 |issue= 4 |pages= 419–24 |year= 1999 |pmid= 10363580 |doi= 10.1111/j.1349-7006.1999.tb00764.x|display-authors=etal|pmc=5926083 }} |
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*{{cite journal | vauthors=Ramírez de Molina A, Penalva V, Lucas L, Lacal JC |title=Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K |journal=Oncogene |volume=21 |issue= 6 |pages= 937–46 |year= 2002 |pmid= 11840339 |doi= 10.1038/sj.onc.1205144 }} |
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*{{cite journal | vauthors=Dubois T, Howell S, Zemlickova E, Aitken A |title=Identification of casein kinase Ialpha interacting protein partners |journal=FEBS Lett. |volume=517 |issue= 1–3 |pages= 167–71 |year= 2002 |pmid= 12062430 |doi=10.1016/S0014-5793(02)02614-5 }} |
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*{{cite journal | vauthors=Ramírez de Molina A, Gutiérrez R, Ramos MA |title=Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy |journal=Oncogene |volume=21 |issue= 27 |pages= 4317–22 |year= 2002 |pmid= 12082619 |doi= 10.1038/sj.onc.1205556 |display-authors=etal}} |
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*{{cite journal | vauthors=Ramírez de Molina A, Rodríguez-González A, Gutiérrez R |title=Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 580–3 |year= 2002 |pmid= 12176020 |doi=10.1016/S0006-291X(02)00920-8 |display-authors=etal}} |
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*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} |
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*{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}} |
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*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} |
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*{{cite journal | vauthors=Gallego-Ortega D, Ramirez De Molina A, Gutierrez R |title=Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer |journal=Int. J. Oncol. |volume=29 |issue= 2 |pages= 335–40 |year= 2006 |pmid= 16820874 |doi= 10.3892/ijo.29.2.335|display-authors=etal|url=https://digital.csic.es/bitstream/10261/24773/1/ijo_29_2_335_PDF.pdf }} |
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*{{cite journal | vauthors=Enaw JO, Zhu H, Yang W |title=CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population |journal=BMC Medicine |volume=4|pages= 36 |year= 2007 |pmid= 17184542 |doi= 10.1186/1741-7015-4-36 | pmc=1770928 |display-authors=etal}} |
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[[Kategori:İnsan kromozom 11 üzerindeki genler]] |
[[Kategori:İnsan kromozom 11 üzerindeki genler]] |
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Sayfanın 18.56, 8 Mart 2020 tarihindeki hâli
Kolin kinaz alfa, insanlarda CHKA geni tarafından kodlanan bir enzimdir.[4][5][6]
Fosfatidilkolin biyosentezi için ana yol, CDP-kolin yolu üzerinden gerçekleşir. Bu gen tarafından kodlanan protein, dizideki ilk enzimdir ve düzenleyici bir rol oynayabilir. Kodlanan protein ayrıca etanolaminin fosforilasyonunu katalize eder. Bu gen için farklı izoformları kodlayan iki transkript türevi bulunmuştur.[6]
Melanositik hücrelerde CHKA gen dışa vurumu MITF tarafından düzenlenebilir.[7]
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000110721 - Ensembl, May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation". FEBS Lett. 304 (2–3). Aug 1992. ss. 229–32.
- ^ "Structure and function of choline kinase isoforms in mammalian cells". Prog Lipid Res. 43 (3). Mar 2004. ss. 266–81.
- ^ a b "Entrez Gene: CHKA choline kinase alpha".
- ^ "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6). 2008. ss. 665–76.
Dış bağlantılar
- İnsan CHKA genomu yerleşimi ve CHKA geni ayrıntıları UCSC Genom Tarayıcısında.
Ek okuma
- Spanner S, Ansell GB (1979). "Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat forebrain". Biochem. J. 178 (3): 753–60. PMC 1186576 $2. PMID 36885.
- Spanner S, Ansell GB (1978). "Choline and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain". Adv. Exp. Med. Biol. 101: 237–45. doi:10.1007/978-1-4615-9071-2_23. PMID 208357.
- Kaplan O, Cohen JS (1994). "Lymphocyte activation-31P magnetic resonance studies of energy metabolism and phospholipid pathways". ImmunoMethods. 4 (2): 139–47. doi:10.1006/immu.1994.1015. PMID 8069533.
- Price DJ, Rivnay B, Fu Y, ve diğerleri. (1997). "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes". J. Biol. Chem. 272 (9): 5915–20. doi:10.1074/jbc.272.9.5915. PMID 9038210.
- Ross BM, Moszczynska A, Blusztajn JK, ve diğerleri. (1997). "Phospholipid biosynthetic enzymes in human brain". Lipids. 32 (4): 351–8. doi:10.1007/s11745-997-0044-x. PMID 9113621.
- Nakagami K, Uchida T, Ohwada S, ve diğerleri. (1999). "Increased choline kinase activity and elevated phosphocholine levels in human colon cancer". Jpn. J. Cancer Res. 90 (4): 419–24. doi:10.1111/j.1349-7006.1999.tb00764.x. PMC 5926083 $2. PMID 10363580.
- Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K". Oncogene. 21 (6): 937–46. doi:10.1038/sj.onc.1205144. PMID 11840339.
- Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Lett. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430.
- Ramírez de Molina A, Gutiérrez R, Ramos MA, ve diğerleri. (2002). "Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy". Oncogene. 21 (27): 4317–22. doi:10.1038/sj.onc.1205556. PMID 12082619.
- Ramírez de Molina A, Rodríguez-González A, Gutiérrez R, ve diğerleri. (2002). "Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers". Biochem. Biophys. Res. Commun. 296 (3): 580–3. doi:10.1016/S0006-291X(02)00920-8. PMID 12176020.
- Strausberg RL, Feingold EA, Grouse LH, ve diğerleri. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 $2. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, ve diğerleri. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, ve diğerleri. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 $2. PMID 15489334.
- Gallego-Ortega D, Ramirez De Molina A, Gutierrez R, ve diğerleri. (2006). "Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer" (PDF). Int. J. Oncol. 29 (2): 335–40. doi:10.3892/ijo.29.2.335. PMID 16820874.
- Enaw JO, Zhu H, Yang W, ve diğerleri. (2007). "CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population". BMC Medicine. 4: 36. doi:10.1186/1741-7015-4-36. PMC 1770928 $2. PMID 17184542.