CKAP5: Revizyonlar arasındaki fark
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"CKAP5" sayfasının çevrilmesiyle oluşturuldu. Etiketler: İçerik Çevirmeni [Çevirmeni 2] |
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| 14. satır: | 14. satır: | ||
== Ek okuma == |
== Ek okuma == |
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* {{cite journal | vauthors = Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW | title = Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans | journal = J. Cell Sci. | volume = 120 | issue = Pt 7 | pages = 1278–87 | year = 2007 | pmid = 17376965 | doi = 10.1242/jcs.000604 }} |
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* {{cite journal | vauthors = Kosturko LD, Maggipinto MJ, D'Sa C, Carson JH, Barbarese E | title = The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2 | journal = Mol. Biol. Cell | volume = 16 | issue = 4 | pages = 1938–47 | year = 2005 | pmid = 15703215 | pmc = 1073673 | doi = 10.1091/mbc.E04-08-0709 }} |
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* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }} |
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* {{cite journal | vauthors = Cassimeris L, Morabito J | title = TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly | journal = Mol. Biol. Cell | volume = 15 | issue = 4 | pages = 1580–90 | year = 2004 | pmid = 14718566 | pmc = 379257 | doi = 10.1091/mbc.E03-07-0544 }} |
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* {{cite journal | vauthors = Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D | title = TACC1-chTOG-Aurora A protein complex in breast cancer | journal = Oncogene | volume = 22 | issue = 50 | pages = 8102–16 | year = 2003 | pmid = 14603251 | doi = 10.1038/sj.onc.1206972 }} |
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* {{cite journal | vauthors = Gergely F, Draviam VM, Raff JW | title = The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells | journal = Genes Dev. | volume = 17 | issue = 3 | pages = 336–41 | year = 2003 | pmid = 12569123 | pmc = 195983 | doi = 10.1101/gad.245603 }} |
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* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }} |
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* {{cite journal | vauthors = Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH | title = Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells | journal = Biochem. J. | volume = 363 | issue = Pt 1 | pages = 195–200 | year = 2002 | pmid = 11903063 | pmc = 1222467 | doi = 10.1042/0264-6021:3630195 }} |
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* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }} |
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* {{cite journal | vauthors = Nakamura S, Grigoriev I, Nogi T, Hamaji T, Cassimeris L, Mimori-Kiyosue Y | title = Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells | journal = PLoS ONE | volume = 7 | issue = 12 | pages = e51442 | year = 2012 | pmid = 23251535 | doi = 10.1371/journal.pone.0051442 | pmc=3520847}} |
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* {{cite journal | vauthors = Zanic M, Widlund PO, Hyman AA, Howard J | title = Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels | journal = Nat. Cell Biol. | volume = 15 | issue = 6 | pages = 688–93 | year = 2013 | pmid = 23666085 | doi = 10.1038/ncb2744 }} |
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[[Kategori:İnsan kromozom 11 üzerindeki genler]] |
[[Kategori:İnsan kromozom 11 üzerindeki genler]] |
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Sayfanın 18.50, 8 Mart 2020 tarihindeki hâli
Hücre iskeletine bağlı protein 5, insanlarda CKAP5 geni tarafından kodlanan mikrotübüle bağlı bir proteindir.[4][5][6] Xenopus'un XMAP215 proteininin[7] homologudur ve ch-Tog olarak da bilinir.
Bunun, en az iki farklı rollere sahiptir iğ ipliği oluşumunda en az iki ayrı rolü vardır: MCAK (KIF2C) aracılığıyla depolimerizasyondan kinetokor mikrotübüllerini korur ve MCAK etkinliğinden bağımsız bir işlev olan sentrozomal mikrotübül birleştiriminde cH-Tog önemli bir rol oynar.[8]
Etkileşimler
CKAP5'in TACC1 ile etkileşime girdiği gösterilmiştir.[9][10]
Kaynakça
- ^ a b c GRCh38: Ensembl release 89: ENSG00000175216 - Ensembl, May 2017
- ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1). Jul 1995. ss. 37–43.
- ^ "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors". Eur. J. Biochem. 234 (2). Feb 1996. ss. 406–13.
- ^ "Entrez Gene: CKAP5 cytoskeleton associated protein 5".
- ^ "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4). 2004. ss. 1580–90.
- ^ "MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics". Mol. Cell. Biol. 28 (23). 2008. ss. 7199–211.
- ^ "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50). Nov 2003. ss. 8102–16.
- ^ "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1). Apr 2002. ss. 195–200.
Dış bağlantılar
- İnsan CKAP5 genomu yerleşimi ve CKAP5 geni ayrıntıları UCSC Genom Tarayıcısında.
Ek okuma
- Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW (2007). "Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans". J. Cell Sci. 120 (Pt 7): 1278–87. doi:10.1242/jcs.000604. PMID 17376965.
- Kosturko LD, Maggipinto MJ, D'Sa C, Carson JH, Barbarese E (2005). "The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2". Mol. Biol. Cell. 16 (4): 1938–47. doi:10.1091/mbc.E04-08-0709. PMC 1073673 $2. PMID 15703215.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446 $2. PMID 15302935.
- Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4): 1580–90. doi:10.1091/mbc.E03-07-0544. PMC 379257 $2. PMID 14718566.
- Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
- Gergely F, Draviam VM, Raff JW (2003). "The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells". Genes Dev. 17 (3): 336–41. doi:10.1101/gad.245603. PMC 195983 $2. PMID 12569123.
- Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 $2. PMID 12421765.
- Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467 $2. PMID 11903063.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Nakamura S, Grigoriev I, Nogi T, Hamaji T, Cassimeris L, Mimori-Kiyosue Y (2012). "Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells". PLoS ONE. 7 (12): e51442. doi:10.1371/journal.pone.0051442. PMC 3520847 $2. PMID 23251535.
- Zanic M, Widlund PO, Hyman AA, Howard J (2013). "Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels". Nat. Cell Biol. 15 (6): 688–93. doi:10.1038/ncb2744. PMID 23666085.