B3GAT3

B3GAT3
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1FGG, 1KWS, 3CU0
Tanımlayıcılar
Başka adlar	B3GAT3
Dış kimlikler	OMIM: 606374 MGI: 1919977 HomoloGene: 56554 GeneCards: B3GAT3
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	62,622,154 bç
RNA ekspresyonu deseni
	; ;
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• transferase activity; • protein phosphatase activator activity; • glucuronosyltransferase activity; • metal ion binding; • GO:0001948, GO:0016582 protein bağlanması; • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;
Hücresel bileşeni	• integral component of membrane; • Golgi aygıtı; • membrane; • cis-Golgi network; • extracellular exosome; • Golgi membrane;
Biyolojik süreci	• positive regulation of intracellular protein transport; • glycosaminoglycan metabolic process; • heparan sulfate proteoglycan biosynthetic process; • GO:0048554 positive regulation of catalytic activity; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • glycosaminoglycan biosynthetic process; • chondroitin sulfate proteoglycan biosynthetic process; • dermatan sulfate proteoglycan biosynthetic process; • chondroitin sulfate metabolic process; • carbohydrate metabolic process; • regulation of phosphoprotein phosphatase activity;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	26229
	72727
	ENSG00000149541
	ENSMUSG00000071649
	O94766
	P58158
	NM_001288721; NM_001288722; NM_001288723; NM_012200
	NM_024256
	NP_001275650; NP_001275651; NP_001275652; NP_036332
	NP_077218
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Galaktozilgalaktozilksilozilprotein 3-beta-glukuronoziltransferaz 3, insanlarda B3GAT3 geni tarafından kodlanan bir enzimdir.^[4]^[5]

Protein, glukuroniltransferaz gen ailesinin üyesi olan bu gen tarafından kodlanmıştır; sıkı alıcı özgüllüğü sergileyen enzimler, indirgenmeyen terminal şekerleri ve bunların anomerik bağlantılarını tanır. Bu gen ürünü, proteoglikanların bağlantı bölgesinin biyosentezinin son aşamasında bir glukuronil transfer reaksiyonu yoluyla glikozaminoglikan-protein bağlantısının oluşumunu katalizler.^[5]

Kaynakça[değiştir | kaynağı değiştir]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149541 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J Biol Chem. 273 (12). Apr 1998. ss. 6615-8.
^ ^a ^b "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

Dış bağlantılar[değiştir | kaynağı değiştir]

Human B3GAT330 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genome location and B3GAT3 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: O947667 Temmuz 2019 tarihinde Wayback Machine sitesinde arşivlendi. (Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)) at the PDBe-KB.

Konuyla ilgili yayınlar[değiştir | kaynağı değiştir]

"Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). 2005. ss. 1173-8.
"Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: A strategy to promote cartilage repair". Proc. Natl. Acad. Sci. U.S.A. 101 (52). 2005. ss. 18087-92.
"Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J. Biol. Chem. 280 (2). 2005. ss. 1417-25.
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). 2004. ss. 2121-7.
"The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif". J. Biol. Chem. 278 (34). 2003. ss. 32219-26.
"Generation and initial analysis of more than 15.000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). 2003. ss. 16899-903.
"Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization". Biochem. J. 358 (Pt 3). 2001. ss. 539-46.
"Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I". J. Biol. Chem. 275 (44). 2000. ss. 34580-5.
"Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues". J. Biol. Chem. 275 (36). 2000. ss. 28254-60.
"Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". FEBS Lett. 459 (3). 1999. ss. 415-20.
"Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway". Proc. Natl. Acad. Sci. U.S.A. 96 (3). 1999. ss. 974-9.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149541 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9506957-4] "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J Biol Chem. 273 (12). Apr 1998. ss. 6615-8.

[entrez-5] "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

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